Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy

Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy

BACKGROUND Four formulations of Tamoxifen citrate loaded polylactide-co-glycolide (PLGA) based nanoparticles (TNPs) were developed and characterized. Their internalization by Michigan Cancer Foundation-7 (MCF-7) breast cancer cells was also investigated. METHODS Nanoparticles were prepared by a multiple emulsion solvent evaporation method. Then the following studies were carried out: drug-exc...

Preparation and characterization of Tribulus terrestris-loaded nanoparticles

Background and objectives: Tribulus terrestris is a flowering herb (Zygophyllaceae) with several properties in folk medicine such as diuretic, tonic, aphrodisiac, analgesic, astringent, and stomachic-lithotripter activities. Although, some extracts and phytochemicals represent excellent bio-activity in vitro, less or no in vivo activity is observed du...

Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer.

This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer. An in vivo study was conducted to determine the effect of Tmx-NPs on DMBA induced mammary tumor in female Wistar rat. The experimental results showed that the mean diameter of Tmx-NPs was 224 ± 3 nm with 68 ± 2% (w/w) of entr...

Biodegradable Guar Gum Nanoparticles as Carrier for Tamoxifen Citrate in Treatment of Breast Cancer

We prepared, characterized and studied the biodistribution of tamoxifen citrate (TMX) loaded cross-linked guar gum (GG) nanoparticles (NPs). NPs were prepared via a single step emulsion process and particle size evaluated. The extent of tissue distribution and retention following oral administration of TMX loaded GG NPs and TMX tablet in female albino mice was analyzed over a period of 48 hours...

preparation and characterization of sub-150 nm protoporphyrin ix-loaded nanoparticles for photodynamic therapy